Neuropharmacology Poster Session
Discussion and Conclusion
I. The pharmacology of quinpirole-stimulated [35S]GTPgammaS binding in rat is consistent with D2-like receptors based on:
1) the rank order of potencies of the dopamine receptor antagonists
2) the ability of the D2 antagonist haloperidol to competitively shift the quinpirole-stimulated [35S]GTPgammaS binding curve rightward.
II. The MAOI clorgyline inhibited quinpirole-stimulated [35S]GTPgammaS binding, however, clorgyline may have inverse agonist or non- selective effects in this model.
III. The MAOIs Ro 41-1049, (+)-Deprenyl and (-)-Deprenyl do not effect quinpirole-stimulated [35S]GTPgammaS binding in rat striatum.
| Discussion Board | Next Page | Your Poster Session |
|Gilliland, S.; Alper, R.; Levant, B.; (1998). Characterization of Quinpirole-Stimulated [35S] GTPgammaS Binding at D2-like Receptors in Rat Striatum.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuropharm/gilliland0401/index.html|
|© 1998 Author(s) Hold Copyright|