Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References

Discussion
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I. The pharmacology of quinpirole-stimulated [35S]GTPgammaS binding in rat is consistent with D2-like receptors based on:

1) the rank order of potencies of the dopamine receptor antagonists

2) the ability of the D2 antagonist haloperidol to competitively shift the quinpirole-stimulated [35S]GTPgammaS binding curve rightward.

II. The MAOI clorgyline inhibited quinpirole-stimulated [35S]GTPgammaS binding, however, clorgyline may have inverse agonist or non- selective effects in this model.

III. The MAOIs Ro 41-1049, (+)-Deprenyl and (-)-Deprenyl do not effect quinpirole-stimulated [35S]GTPgammaS binding in rat striatum.

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