Invited Symposium: Oxidative Stress and the CNS



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Nutritional Regulation of Peroxide Scavenging

Contact Person: Phyllis G. Paterson (patersnp@duke.usask.ca)


  1. Chan, P. H. Oxygen radicals in focal cerebral ischemia, Brain Pathol. 4: 59-65, 1994.
  2. Grace, P. A. Ischaemia-reperfusion injury, Br. J. Surg. 81: 637-647, 1994.
  3. Gutteridge, J. M. C. and Halliwell, B. Reoxygenation injury and antioxidant protection: A tale of two paradoxes, Arch. Biochem. Biophys. 283: 223-226, 1990.
  4. Halliwell, B. Free radicals and antioxidants: A personal view, Nutr. Rev. 52: 253-265, 1994.
  5. Halliwell, B. Antioxidants in human health and disease, Annu. Rev. Nutr. 16: 33-50, 1996.
  6. Juurlink, B. H. J. Central role of glutathione in governing the response of astroglial and oligodendroglial cells to ischemia-related insults, Recent Res. Devel. Neurochem. 1: 179-192, 1996.
  7. Hall, E. D. Cerebral ischemia, free radicals and antioxidant protection, Biochem. Soc. Trans. 21: 334-339, 1993.
  8. Juurlink, B. H. J. Response of glial cells to ischemia: Roles of reactive oxygen species and glutathione, Neurosci. Biobehav. Rev. 21: 151-166, 1997.
  9. Juurlink, B. H. J. and Sweeney, M. I. Mechanisms that result in damage during and following cerebral ischemia, Neurosci. Biobehav. Rev. 21: 121-128, 1997.
  10. Halliwell, B. and Gutteridge, J. M. C. Role of free radicals and catalytic metal ions in human disease: An overview, Methods Enzymol. 186: 1-85, 1990.
  11. Halliwell, B. and Cross, C. E. Oxygen-derived species: Their relation to human disease and environmental stress, Environ. Health Perspect. 102S: 5-12, 1994.
  12. Yamaguchi, T., Sano, K., Takakura, K., Saito, I., Shinohara, Y., Asano, T., and Yasuhara, H. Ebselen in acute ischemic stroke. A placebo-controlled, double-blind clinical trial, Stroke. 29: 12-17, 1998.
  13. Mizui, T., Kinouchi, H., and Chan, P. H. Depletion of brain glutathione in by buthionine sulfoximine enhances cerebral ischemic injury in rats., Am. J. Physiol. 262: H313-H317, 1992.
  14. Gotoh, O., Yamamoto, M., Tamura, A., and Sano, K. Effect of YM737, a new glutathione analogue, on ischemic brain edema, Acta Neurochir. Suppl. Wein. 60: 318-320, 1994.
  15. Knuckey, N. W., Palm, D., Primiano, M., Epstein, M. H., and Johanson, C. E. N-acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats, Stroke. 26: 305-311, 1995.
  16. Lipschitz, D. A. Malnutrition in the elderly, Sem. Dermatol. 10: 273-281, 1991. Abbasi, A. A. and Rudman, D. Undernutrition in the nursing home: Prevalence, consequences, causes and prevention, Nutr. Rev. 52: 113-122, 1994.
  17. Bray, T. M. and Taylor, C. G. Tissue glutathione, nutrition, and oxidative stress, Can. J. Physiol. Pharmacol. 71: 746-751, 1993.
  18. Taylor, C. G., Nagy, L. E., and Bray, T. M. Nutritional and hormonal regulation of glutathione homeostasis, Curr. Top. Cell. Regul. 34: 189-208, 1996.
  19. Meister, A., Anderson, M. E., and Hwang, O. Intracellular cysteine and glutathione delivery systems, J. Amer. Coll. Nutr. 5: 137-151, 1986.
  20. Bauman, P. F., Smith, T. K., and Bray, T. M. The effect of dietary protein and sulfur amino acids on hepatic glutathione concentration and glutathione-dependent enzyme activities in the rat, Can. J. Physiol. Pharmacol. 66: 1048-1052, 1988.
  21. Taylor, C. G., Bauman, P. F., Sikorski, B., and Bray, T. M. Elevation of lung glutathione by oral supplementation of L-2-oxothiazolidine-4-carboxylate protects against oxygen toxicity in protein-energy malnourished rats, FASEB J. 6: 3101-3107, 1992.
  22. Benuck, M., Banay-Schwartz, M., DeGuzman, T., and Lajtha, A. Effect of food deprivation on glutathione and amino acid levels in brain and liver of young and aged rats, Brain Res. 678: 259-264, 1995.
  23. Hum, S., Koski, K. G., and Hoffer, L. J. Varied protein intake alters glutathione metabolism in rats, J. Nutr. 122: 2010-2018, 1992.
  24. Tor-Agbidye, J., Palmer, V., Blythe, L., Craig, A. M., Spencer, P. S., and Sabri, M. I. Rat brain glutathione is selectively depleted in dietary sulfur amino acid deficiency (abstract), Soc. Neurosci. Abstr. 22: 2135, 1996.
  25. Mesina, J. E., Page, R. H., Hetzel, F. W., and Chopp, M. Administration of L-2-oxothiazolidine-4-carboxylate increases glutathione levels in rat brain, Brain Res. 478: 181-183, 1989.
  26. Anderson, M. E. and Meister, A. Intracellular delivery of cysteine, Meth. Enzymol. 143: 313-325, 1987.
  27. Buckman, T. D., Sutphin, M. S., and Eckhert, C. D. A comparison of the effects of dietary selenium on selenoprotein expression in rat brain and liver, Biochim. Biophys. Acta. 1163: 176-183, 1993.
  28. Knight, S. A. B. and Sunde, R. A. The effect of progressive selenium deficiency on anti-glutathione peroxidase antibody reactive protein in rat liver, J. Nutr. 117: 732-738, 1987.
  29. Burk, R. F. and Hill, K. E. Regulation of selenoproteins., Annu. Rev. Nutr. 1993: 65-81, 1993.
  30. Lei, X. G., Evenson, J. K., Thompson, K. M., and Sunde, R. A. Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium, J. Nutr. 125: 1438-1446, 1995.
  31. Watanabe, C. and Satoh, H. Brain selenium status and behavioral development in selenium-deficient preweanling mice, Physiol. Behav. 56: 927-932, 1994.
  32. Lawrence, R. A., Sunde, R. A., Schwartz, G. L., and Hoekstra, W. G. Glutathione peroxidase activity in rat lens and other tissues in relation to dietary selenium intake, Exp. Eye Res. 18: 563-569, 1974.
  33. Beckett, G. J., MacDougall, D. A., Nicol, F., and Arthur, J. R. Inhibition of type I and type II iodothyronine deiodinase activity in rat liver, kidney and brain produced by selenium deficiency, Biochem. J. 259: 887-892, 1989.
  34. Whanger, P. D. and Butler, J. A. Effects of various dietary levels of selenium as selenite or selenomethionine on tissue selenium levels and glutathione peroxidase activity in rats, J. Nutr. 118: 846-852, 1988.
  35. Castaño, A., Cano, J., and Machado, A. Low selenium diet affects monoamine turnover differentially in substantia nigra and striatum, J. Neurochem. 61: 1302-1307, 1993.
  36. Prohaska, J. R. and Ganther, H. E. Selenium and glutathione peroxidase in developing rat brain, J. Neurochem. 27: 1379-1387, 1976.
  37. Reeves, P. G., Nielsen, F. H., and Fahey, G. C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet, J. Nutr. 123: 1939-1951, 1993.
  38. Baker, D. H. and Boebel, K. P. Utilization of D-isomers of arginine and histidine by chicks and rats, J. Anim. Sci. 53: 125-129, 1981.
  39. Komura, C., Ono, K., Shibamoto, Y., Nishidai, T., Takahashi, M., and Abe, M. Rapid and simple method for quantitative determination of non-protein sulphydryls in mouse liver by reversed-phase high-performance liquid chromatography, J. Chromatography. 338: 209-212, 1985.
  40. Thorburne, S. K. and Juurlink, B. H. J. Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress, J. Neurochem. 67: 1014-1022, 1996.
  41. Kodama, K. Stroke trends in Japan, Ann. Epidemiol. 3: 524-528, 1993.
  42. Omura, T., Hisamatsu, S., Takizawa, Y., Minowa, M., Yanagawa, H., and Shigematsu, I. Geographical distribution of cerebrovascular disease mortality and food intakes in Japan, Soc. Sci. Med. 24: 401-407, 1987.
  43. Kagan, A., Popper, J. S., Rhoads, G. G., and Yano, K. Dietary and other risk factors for stroke in Hawaiian Japanese men, Stroke. 16: 390-396, 1985.
  44. Mowé, M. and Bøhmer, T. The prevalence of undiagnosed protein-calorie undernutrition in a population of hospitalized elderly patients, J. Am. Geriatr. Soc. 39: 1089-1092, 1991.
  45. Constans, T., Bacq, Y., Bréchot, J.-F., Guilmot, J.-L., Choutet, P., and Lamisse, F. Protein-energy malnutrition in elderly medical patients, J. Amer. Geriatr. Soc. 40: 263-268, 1992.
  46. Potter, J., Klipstein, K., Reilly, J. J., and Roberts, M. The nutritional status and clinical course of acute admissions to a geriatric unit, Age Ageing. 24: 131-136, 1995.
  47. Lesourd, B. Protein undernutrition as the major cause of decreased immune function in the elderly: Clinical and functional implications, Nutr. Rev. 53: S86-S94, 1995.
  48. Dávalos, A., Ricart, W., Gonzalez-Huix, F., Soler, S., Marrugat, J., Molins, A., Suñer, R., and Genís, D. Effect of malnutrition after acute stroke on clinical outcome, Stroke. 27: 1028-1032, 1996.
  49. Axelsson, K., Asplund, K., Norberg, A., and Alafuzoff, I. Nutritional status in patients with acute stroke, Acta Med. Scand. 224: 217-224, 1988.
  50. Gariballa, S. E., Parker, S. G., Taub, N., and Castleden, M. Nutritional status of hospitalized acute stroke patients, Br. J. Nutr. 79: 481-487, 1998.
  51. Choi-Kwan, S., Yang, Y. H., Kim, E. K., Jeon, M. Y., and Kim, J. S. Nutritional status in acute stroke: undernutrition versus overnutrition in different stroke subtypes, Acta Neurol. Scand. 98: 187-192, 1998.
  52. Finestone, H. M., Greene-Finestone, L. S., Wilson, E. S., and Teasell, R. W. Malnutrition in stroke patients on the rehabilitation service and at follow-up: Prevalence and predictors, Arch. Phys. Med. Rehabil. 76: 310-316, 1995.
  53. Bermano, G., Nicol, F., Dyer, J. A., Sunde, R. A., Beckett, G. J., Arthur, J. R., and Hesketh, J. E. Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats, Biochem. J. 311: 425-430, 1995.
  54. Weiss, S. L., Evenson, J. K., Thompson, K. M., and Sunde, R. A. The selenium requirement for glutathione peroxidase mRNA level is half of the selenium requirement for glutathione peroxidase activity in female rats, J. Nutr. 126: 2260-2267, 1996.

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Paterson, P.G.; (1998). Nutritional Regulation of Peroxide Scavenging. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/juurlink/paterson0526/index.html
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