Invited Symposium: Oxidative Stress and the CNS



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Nutritional Regulation of Peroxide Scavenging

Contact Person: Phyllis G. Paterson (patersnp@duke.usask.ca)


Short-term dietary sulfur amino acid deficiency depressed liver GSH concentration by 74% in the sulfur-deficient group. GSH declined 10-14% in the brain regions examined, and this was significant in the neocortex and thalamus. Regional differences in brain GSH concentration were apparent, with the highest concentrations in hippocampus and striatum.

In the selenium study, Se deficiency was confirmed by liver GPX activity < 7% of controls. Our preliminary data to date have not shown a response of brain GPX activity to the level of dietary Se in any brain region analyzed so far.

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Paterson, P.G.; (1998). Nutritional Regulation of Peroxide Scavenging. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/juurlink/paterson0526/index.html
© 1998 Author(s) Hold Copyright