Cancer Poster Session
When a cell is exposed to strong high-voltage and short electric pulses, the cell membrane can be opened transiently without causing a permanent damage of cell. This electroporation made possible the insertion of genetic material into the living cells(1). Recently, the technique of this electroporation was applied to a potential cancer treatment termed electrochemotherapy(2-6). The electrochemotherapy uses electroporation as a means to deliver anti-cancer drugs directly to the cytoplasm of the tumor cells. As far as the metastatic lesions of oral tumors are concerned, the effects of this therapy have yet not been investigated. Therefore, using hamster oral fibrosarcoma, which can metastasize to the regional lymph nodes, transplanted in the cheek pouch mucosa, the present study evaluated whether electrochemotherapy had the anti-tumor effect on the metastatic lesions of this type of tumor. Syrian golden hamsters with the metastatic lesions of oral fibrosarcoma submucosally transplanted in the cheek pouch mucosa were treated with intraperitoneal injection of cyclophosphamide(CPA) followed by local delivery of electric pulses using BTX electroporation unit at the the metastatic tumor site of the regional lymph node.
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|Maeda, H; Kojima, A; Sugita, Y; Tanaka, S; Kubo, K; Sato, E; Konishi, S; Tanaka, H; Kameyama, Y; (1998). Electrochemotherapy Potentiation of Antitumor Effect of Cyclophosphamide by Local Electric Pulses on the Metastatic Lesion of Hamster Oral Fibrosarcoma. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/cancer/maeda0671/index.html|
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