Invited Symposium: Stroke/Cerebral Vasospasm



Materials & Methods


Discussion & Conclusion



INABIS '98 Home Page Your Session Symposia & Poster Sessions Plenary Sessions Exhibitors' Foyer Personal Itinerary New Search

Mitogen-Activated Protein Kinase Is Involved In The Pathogenesis Of Cerebral Vasospasm

Contact Person: Alexander Y. Zubkov, MD (szubkov@neurosurgery.umsmed.edu)


  1. Adam, L.P.; Franklin, M.T.; Raff, G.J.; Hathaway, D.R. Activation of mitogen-activated protein kinase in porcine carotid arteries. Circ Res 76:183-190; 1995.
  2. Adam, L.P.; Hathaway, D.R. Identification of mitogen-activated protein kinase phosphorylation sequences in mammalian h-Caldesmon. FEBS Lett 322:56-60; 1993.
  3. Alessi, D.R.; Cuenda, A.; Cohen, P.; Dudley, D.T.; Saltiel, A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494; 1995.
  4. Berk, B.C.; Corson, M.A. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res 80:607-616; 1997.
  5. Childs, T.J.; Mak, A.S. Smooth-muscle mitogen-activated protein (MAP) kinase: purification and characterization, and the phosphorylation of caldesmon. Biochem J 296:745-751; 1993.
  6. Earley, J.J.; Su, X.; Moreland, R.S. Caldesmon inhibits active crossbridges in unstimulated vascular smooth muscle: an antisense oligodeoxynucleotide approach. Circ Res 83:661-667; 1998
  7. Epstein, A.M.; Throckmorton, D.; Brophy, C.M. Mitogen-activated protein kinase activation: an alternate signaling pathway for sustained vascular smooth muscle contraction. J Vasc Surg 26:327-332; 1997.
  8. Force, T.; Bonventre, J.V. Growth factors and mitogen-activated protein kinases. Hypertension 31:152-161; 1998.
  9. Fukami, M.; Tani, E.; Takai, A.; Yamaura, I.; Minami, N. Activity of smooth muscle phosphatases 1 and 2A in rabbit basilar artery in vasospasm. Stroke 26:2321-2327; 1995.
  10. Glenney, J.R., Jr. Tyrosine-phosphorylated proteins: mediators of signal transduction from the tyrosine kinases. Biochim Biophys Acta 1134:113-127; 1992.
  11. Griendling, K.K.; Ushio-Fukai, M.; Lassegue, B.; Alexander, R.W. Angiotensin II signaling in vascular smooth muscle. New concepts. Hypertension 29:366-373; 1997.
  12. Hardy, K.; Chaudhri, G. Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes. Immunol Cell Biol 75:528-545; 1997.
  13. Katoch, S.S.; Moreland, R.S. Agonist and membrane depolarization induced activation of MAP kinase in the swine carotid artery. Am J Physiol 269:H222-H2291995.
  14. Khalil, R.A.; Morgan, K.G. PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation. Am J Physiol 265:C406-C4111993.
  15. Kim, C.-J.; Kim, K.-W.; Park, J.-W.; Lee, J.-C.; Zhang, J.H. Role of tyrosine kinase in erithrocyte lysate-induced contraction in rabbit cerebral arteries. J Neurosurg 89:289-296; 1998.
  16. Kribben, A.; Wieder, E.D.; Li, X.; van, P.V.; Granot, Y.; Schrier, R.W.; Nemenoff, R.A. AVP-induced activation of MAP kinase in vascular smooth muscle cells is mediated through protein kinase C. Am J Physiol 265:C939-C9451993.
  17. Macdonald, R.L.; Weir, B.K. Cerebral vasospasm and free radicals. Free Radic Biol Med 16:633-643; 1994.
  18. Mario Zuccarello; Riccardo Boccaletti; Alberto Romano; Robert M.Rapoport Endothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage–Induced Cerebral Vasospasm. Stroke 29:1924-1929; 1998.
  19. Marton, L.S.; Weir, B.K.; Zhang, H. Tyrosine phosphorylation and [Ca2+]i elevation induced by hemolysate in bovine endothelial cells: implications for cerebral vasospasm. Neurol Res 18:349-353; 1996.
  20. Matsui, T.; Asano, T. Protein kinase C and vasospasm. J Neurosurg 85:1197-1198; 1996.
  21. Nishizawa, S.; Yamamoto, S.; Uemura, K. Interrelation between protein kinase C and nitric oxide in the development of vasospasm after subarachnoid hemorrhage. Neurol Res 18:89-95; 1996.
  22. Onoda, K.; Ono, S.; Ogihara, K.; Shiota, T.; Asari, S.; Ohmoto, T.; Ninomiya, Y. Inhibition of vascular contraction by intracisternal administration of preproendothelin-1 mRNA antisense oligoDNA in a rat experimental vasospasm model. J Neurosurg 85:846-852; 1996.
  23. Pelech, S.L.; Sanghera, J.S. MAP kinases: charting the regulatory pathways. Science 257:1355-1356; 1992.
  24. Sato, M.; Tani, E.; Matsumoto, T.; Fujikawa, H.; Imajoh-Ohmi, S. Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery. J Neurosurg 87:752-756; 1997.
  25. Schulze-Osthoff, K.; Ferrari, D.; Riehemann, K.; Wesselborg, S. Regulation of NF-kappa B activation by MAP kinase cascades. Immunobiology 198:35-49; 1997.
  26. Sugden, P.H.; Clerk, A. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cell Signal 9:337-351; 1997.
  27. Watson, M.H.; Venance, S.L.; Pang, S.C.; Mak, A.S. Smooth muscle cell proliferation. Expression and kinase activities of p34cdc2 and mitogen-activated protein kinase homologues. Circ Res 73:109-117; 1993.
  28. Zhang J; Lewis A.I.; Bernanke D.H.; Zubkov A.Y.; Clower B. Stroke:Anatomy of A Catastrophic Event. The Anat Rec (New Anat) 253:58-63; 1998.
  29. Zubkov AY; Lewis AI; Scalzo D; Bernanke DH; Harkey HL Morphological Changes after Percutaneous Transluminal Angioplasty. Surg Neurol 1998.(in press)

    Back to the top.

    <= Discussion & Conclussions REFERENCES

    | Discussion Board | Next Page | Your Symposium |
Zubkov, A.Y.; Ogihara, K.; Tumu, P.; Lewis, A.I.; (1998). Mitogen-Activated Protein Kinase Is Involved In The Pathogenesis Of Cerebral Vasospasm. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/zhang/zubkov0457/index.html
© 1998 Author(s) Hold Copyright