Invited Symposium: Hypertension III: Flow-Induced Vascular Remodeling



Materials & Methods


Discussion & Conclusion



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Nitric Oxide Synthase and Growth Factor Expression in Flow-Induced Arterial Remodeling in Rat Mesenteric Vasculature

Contact Person: David A. Tulis (DAMIT@RUF.RICE.EDU)


  1. Walpola, P.L., A.I. Gotlieb, and B.L. Langille. (1993) Monocyte adhesion and changes in endothelial cell number, morphology, and f-actin distribution elicited by low shear stress in vivo. Am. J. Pathol. 142: 1392 - 1400.
  2. Wang, D.H., and R.L. Prewitt. (1991) Microvascular development during normal growth and reduced blood flow: introduction of a new model. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H1966 - H1972.
  3. Hsieh, H-J., N-Q. Li, and J.A. Frangos. (1993) Pulsatile and steady flow induces c-fos expression in human endothelial cells. J. Cell. Physiol. 154: 143 - 151.
  4. Lan, Q., O. Mercurius, and P.F. Davies. (1994) Stimulation of transcription factors NFkB and AP1 in endothelial cells subjected to shear stress. Biochem. Biophys. Res. Comm. 201: 950 - 956.
  5. Mitsumata, M., R.S. Fishel, R.M. Nerem, R.W. Alexander, and B.C. Berk. (1993) Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H3 - H8.
  6. Ranjan, V., and S.L. Diamond. (1993) Fluid shear stress induces synthesis and nuclear localization of c-fos in cultured human endothelial cells. Biochem. Biophys. Res. Comm. 196: 79 - 84.
  7. Kaiser, L., and H.V. Sparks, Jr. (1986) Mediation of flow-dependent dilation by endothelial cells. Circulatory Shock 18: 109 - 114.
  8. Smiesko, V., J. Kozík, and S. Dolezel. (1985) Role of endothelium in the control of arterial diameter by blood flow. Blood Vessels 22: 247 - 251.
  9. Smiesko, V., D.J. Lang, and P.C. Johnson. (1989) Dilator response of rat mesenteric arcading arterioles to increased blood flow velocity. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1958 - H1965.
  10. Unthank, J.L., S.W. Fath, H.M. Burkhart, S.C. Miller, and M.C. Dalsing. (1996) Wall remodeling during luminal expansion of mesenteric arterial collaterals in the rat. Circ. Res. 79: 1015 - 1023.
  11. Unthank, J.L., J.C. Nixon, H.M. Burkhart, S.W. Fath, and M.C. Dalsing. (1996) Early collateral and microvascular adaptations to intestinal artery occlusion in the rat. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H914 - H923.
  12. Malek AM, Gibbons GH, Dzau VJ, Izumo S. (1993) Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J. Clin. Invest. 92:2013-2021.
  13. Ohno M, Cooke JP, Dzau VJ, Gibbons GH. (1995) Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production: modulation by potassium channel blockade. J. Clin. Invest. 95:1363-1369.
  14. Malek AM, Greene AL, Izumo S (1993) Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Proc. Natl. Acad. Sci. USA, 90:5999-6003.
  15. Hsieh H-J, Li N-Q, Frangos JA (1991) Shear stress increases endothelial platelet-derived growth factor mRNA levels. Am. J. Physiol. 260 (Heart Circ. Physiol. 29):H642-H646.
  16. Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey, Jr. CF, Gimbrone, Jr. MA (1993) Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc. Natl. Acad. Sci. USA 90:4591-4595.
  17. Bonthron DT, Morton CC, Orkin SH, Collins T (1988) Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing. Proc. Natl. Acad. Sci. USA 85:1492-1496.
  18. Wilcox J (1993) Fundamental principles of in situ hybridization. J. Histochem. Cytochem. 41:1725-1733.
  19. Koller, A., and G. Kaley. (1991) Endothelial regulation of wall shear stress and blood flow in skeletal muscle microcirculation. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H862 - H868.
  20. Kraiss, L.W., T.R. Kirkman, T.R. Kohler, B. Zierler, and A.W. Clowes. (1991) Shear stress regulates smooth muscle proliferation and neointimal thickening in porous polytetrafluoroethylene grafts. Arteriosclerosis Thromb.11: 1844 - 1852.
  21. Bardy, N., G.J. Karillon, R. Merval, J-L. Samuel, and A. Tedgui. (1995) Differential effects of pressure and flow on DNA and protein synthesis and on fibronectin expression by arteries in a novel organ culture system. Circ. Res. 77: 684 - 694.
  22. Zarins, C.K., M.A. Zatina, D.P. Giddens, D.N. Ku, and S. Glagov. (1987) Shear stress regulation of artery lumen diameter in experimental atherogenesis. J. Vasc. Surg. 5: 413 - 420.
  23. Wilson E, Mai Q, Sudhir K, Weiss RH, Ives HE: (1993) Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF. J. Cell Biol. 123:741-747.
  24. Miano JM, Vlasic N, Tota RR, Stemerman MB (1993) Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury. Arterio. Thromb. 13:211-219.
  25. Walker LN, Bowen-Pope DF, Ross R, Reidy MA (1986) Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. Proc. Natl. Acad. Sci. USA 83:7311-7315.
  26. Vlodavsky I, Fridman R, Sullivan R, Sasse J, Klagsbrun M (1987) Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet-derived growth factor-like protein which is secreted. J. Cell. Physiol. 131:402-408.
  27. Bobik A, Campbell JH (1993) Vascular derived growth factors: cell biology, pathophysiology, and pharmacology. Pharm. Rev. 45:1-42.
  28. Daemen MJAP, De Mey JGR (1995) Regional heterogeneity of arterial structural changes. Hypertension 25:464-473.
  29. Field SL, Khachigian LM, Sleigh MJ, Yang G, Vandermark SE, Hogg PJ, Chesterman CN (1996) Extracellular matrix is a source of mitogenically active platelet-derived growth factor. J. Cell. Physiol. 168:322-332.

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Tulis, DA; Unthank, JL; Prewitt, RL; (1998). Nitric Oxide Synthase and Growth Factor Expression in Flow-Induced Arterial Remodeling in Rat Mesenteric Vasculature. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/prewitt/tulis0444/index.html
© 1998 Author(s) Hold Copyright