Pharmacology & Toxicology Poster Session
Discussion and Conclusion
There are three primary uses for the osmotic pressure in our lab. First, the osmotic pressure test can be used to compare the strength of new types of microcapsules. The test allows us to quantitatively show that one type of microcapsule is stronger than another type and thus will facilitate the development of stronger microcapsules. Second, the osmotic pressure test can be used to identify factors that weaken the microcapsules in vivo. By measuring the strength of a batch of microcapsules periodically while exposing the capsules to a factor that may weaken the microcapsule, it will be possible to identify factors that contribute to the weakening of the microcapsules. It should also be possible to use the test to determine which capsules are least susceptible to the weakening factors. Last, the osmotic pressure test can be used to improve current encapsulation protocols. By testing microcapsules made with minor variations of our standard encapsulation protocol it should be possible to optimize our encapsulation conditions with the ultimate goal of developing stronger microcapsules.
In conclusion, the low levels of delivery seen in dogs has indicated a need for the creation of stronger microcapsules. The osmotic pressure test provides a quantitative means of developing stronger microcapsules and identifying the specific factors involved with weakening the microcapsules. The development of stronger microcapsules will presumably lead to a longer survival of the microcapsule and in turn a prolonged period of therapeutic protein delivery. It may also be informative to take into consideration the degree of breakage seen with the microcapsule since this too may indicate differences in microcapsule strength.
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|Van Raamsdonk, J.; Chang, P.; (1998). Towards Stronger Microcapsules for Non-Autologous Somatic Gene Therapy. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/pharmtox/van_raamsdonk0239/index.html|
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