Pharmacology & Toxicology Poster Session



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the Role of Divalent Cations in the Mechanisms of EDTA Cytotoxicity

Contact Person: Michael O. Ogundele (mogundel@yahoo.com)


1. Beales D; Hue DP; McLean AE. 1985 Lipid peroxidation, protein synthesis, and protection by calcium EDTA in paracetamol injury to isolated hepatocytes. Biochem Pharmacol. 34(1): 19-23

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3. Brownie-CF; Brownie-C; Noden-D; Krook-L; Haluska-M; Aronson-AL. 1986 Teratogenic effect of calcium edetate (CaEDTA) in rats and the protective effect of zinc. Toxicol-Appl-Pharmacol. 82(3): 426-43

4. Grass GM; Robinson JR. 1988 Mechanisms of corneal drug penetration. I: In vivo and in vitro kinetics. J Pharm Sci. 77(1): 3-14

5. Grass GM; Wood RW; Robinson JR. 1985 Effects of calcium chelating agents on corneal permeability. Invest Ophthalmol Vis Sci. 26(1): 110-3

6. Grubbs RD; Wetherill CA; Kutschke K; Maguire ME. 1985 Magnesium transport in murine S49 lymphoma cells: pharmacology and divalent cation selectivity. Am J Physiol. 248(1 Pt 1): C51-7

7. Kane MH; Rodman JS; Horten B; Reckler J; Marion D; Vaughan ED Jr 1989 Urothelial injury from ethylenediaminetetraacetic acid used as an irrigant in the urinary tract. J Urol. 142(5): 1359-60

8. MacDonald JR; Gandolfi AJ; Sipes IG 1985 Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol Appl Pharmacol. 81(1): 17-24

9. Mayer M.M. Complement and Complement fixation. In Experimental Immunochemistry (2nd edition) Kabat E.A., Mayer M.M., editors. Charles C. Thomas, Publisher, Springfield, IL pp. 133-240 (1971)

10. Naccache P.H., Showell H.J., Becker E.L., Sha`afi R.I. 1979 Involvement of membrane calcium in the response of rabbit neutrophils to chemotactic factors as evidenced by fluorescence of chlortetracycline. J. Cell Biol. 83:179-86.

11. Papadimitriou-JC; Drachenberg-CB; Shin-ML; Trump-BF. 1994 Ultrastructural studies of complement mediated cell death: a biological reaction model to plasma membrane injury. Virchows-Arch.; 424(6): 677-85

12. Patel T., Bronk S.F., Gores G.J. 1994 Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J. Clin. Invest. 94(6):2183-92.

13. Rosenblatt D.E., Doyle D:G., Aronson A.L. 1978 Calcium ethylenediaminetetraacetate (Ca EDTA) toxicity: time- and dose-dependent studies on intestinal morphology in the rat. Exp. Mol. Pathol. 28(2):215-26

14. Tucker-JD; Chritsensen-ML. 1987 Effects of anticoagulants upon sister-chromatid exchanges, cell-cycle kinetics, and mitotic index in human peripheral lymphocytes. Mutat-Res. 190(3): 225-8

15. van-de-Water B; Zoetewey JP; de-Bont HJ; Mulder GJ; Nagelkerke JF. 1993 The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine. Biochem Pharmacol. 45(11): 2259-67

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<= Discussion & Conclussions REFERENCES

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Ogundele, M.O.; (1998). the Role of Divalent Cations in the Mechanisms of EDTA Cytotoxicity. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/pharmtox/ogundele0173/index.html
© 1998 Author(s) Hold Copyright