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Reproductive Toxicity of Cadmium

Massanyi, P (University of Agriculture, Tr. A. Hlinku 2, Slovak Republic)
Uhrin, V (University of Constantin Philosopher, Tr. A. Hlinku 1, Slovak Republic)
Toman, R (University of Agriculture, Tr. A. Hlinku 2, Slovak Republic)
Lukac, N (University of Agriculture, Tr. A. Hlinku 2, Slovak Republic)
Pizzi, F (Consiglio Nazionale delle Ricerche, Via Celoria 10, Italy)
Renon, P (Universita degli Studi di Milano, Via Graselli 7, Italy)
Paksy, K (National Institute of Occupational Medicine, Nagyvarad ter 2, Hungary)
Forgacs, Z S (National Institute of Occupational Medicine, Nagyvarad ter 2, Hungary)
Trandzik, J (State Breeding Service, Hlohovska 5, Slovak Republic)

Contact Person: Peter Massanyi (massanyi@afnet.uniag.sk)


The results of our study show that: 1, cadmium mainly accumulates in oviduct followed by ovary and uterus (levels in testicles and tunica albuginea of testis are lower) 2, decrese percentual content of growing follicles in ovary (from 31% in control animals to 5-10% in animals with cadmium administration) 3, causes the follicular atresia (atresia is time and mainly dose dependent) 4, changes the ultrastructure of granulosa cells (vacoulization of cytoplasm, alteration of mitochondria structure, increse of the number of lipid drops, luteinisation) 5, altersprogesterone and 17-beta-oestradiol production of granulosa cells (incrase of progesterone and decrase of 17-beta-oestradiol in the media) 6, causes oedamatisation of stroma in oviduct (with changes in wall of capilleries and subsequent diapedesis) 7, decrese percentage of glandular epitheliu a increase amount of stroma in uterus (oedamatisation caused by damage of vascular wall) 8, decrease of germinal epithelium and increase stroma in testicle (changes are time and dose dependent) 9, higher doses inhibit spermatozoa motility parameters in vitro (in lower doses motility of spermatozoa is not affected, in higher doses mainly progressive motility and path velocity are effected) 10, decrease the weight of offspring, but no malformations were found

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Poster Number PAmassanyi0161

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Massanyi, P; Uhrin, V; Toman, R; Lukac, N; Pizzi, F; Renon, P; Paksy, K; Paksy, Z S; Trandzik, J; (1998). Reproductive Toxicity of Cadmium. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/occupational/massanyi0161/index.html
© 1998 Author(s) Hold Copyright