Immunology & Immunological Disorders Poster Session
Lysozyme was added to the serum as a source of C in CH50 whole C assays. Concentrations ranging from 50 to 1500 microgrammes per millilitre were added, corresponding to expected physiological and pathological levels of lysozyme in the colostrum, mature or inflammed breast-milk, as well as other normal and inflammed body fluids. Lysozyme was found to inhibit the classical pathway of serum complement activity in a dose-dependent fashion within the concentration ranges tested (Fig. 1).
Figure 1 Inhibitory effect of human purified lysozyme on serum complement activities
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|Ogundele, M.O.; (1998). A Novel Anti-inflammatory Activity of Human Lysozyme: Modulation of Serum Complement Activation. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/immunology/ogundele0178/index.html|
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