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Invited Symposium: Cytokines, Monoamines and Behavior






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
Board

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Sensitization Effects of TNF-alpha: Behavioral and Neurochemical Processes


Contact Person: Shawn Hayley (shayley@ccs.carleton.ca)


References

  1. Benigni F, Faggioni R, Sironi M, Fantuzzi G, Vandenabeele P, Takahashi N, Sacco S, Fiers W, Buurman WA and Ghezzi P. (1996). TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF. J Immunol, 157, 5563-5568.
  2. Beutler B., Milsark I.W. and Cerami A.C. (1985). Passive immunization against cachectin/tumor necrosis factor protects mice from the lethal effects of endotoxin. Science, 229, 869.
  3. Dantzer R, Bluthe RM, Aubert A, Goodall G, Bret-Dibat J-L, Kent S, Goujon E, Laye S, Parnet P and Kelley KW (1996). Cytokine actions on behavior. In: Rothwell NJ (ed) Cytokines and the Nervous System. Landes, London, pp 117-144.
  4. Dunn AJ (1992). The role of interleukin-1 and tumor necrosis factor alpha in the neurochemical and neuroendocrine responses to endotoxin. Brain Res Bull,6 807-12.
  5. Dunn AJ, (1988a). Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism paralleling the increased plasma corticosterone. Life Sci. 43: 429-435.
  6. Ignatowski TA, Noble BK, Wright JR, Gorfien JL, Heffner RR and Spengler RN (1997). Neuronal-associated tumor necrosis factor (TNF-); it's role in noradrenergic functioning and modification of it's expression following antidepressant drug administraiton. J. Neuroimmunol., 79, 84-90.
  7. Linthorst, A.C.E., Flachskamm, C., Muller-Preuss, P. Holsboer, F. and Reul, J.M.H.M. (1995). Effect of bacterial endotoxin and interleukin-1 on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: An in vivo microdialysis study. J. Neurosci., 15, 2920-2934.
  8. Merali Z, Lacosta S, and Anisman H (1997) Effects of interleukin-1 and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: A regional microdialysis study. Brain Res 761: 225-235
  9. Plata-Salaman C.R., Oomura Y. and Kai Y. (1988). Tumor necrosis factor and interleukin-1: suppression of food intake by direct action in the central nervous system. Brain Res, 448, 106-114.
  10. Shintani, F., Kanba, S., Nakaki, T., Nibuya, M., Kinoshita, N., Suzuki, E., Yagi, G., Kato, R. and Asai M. (1993). Interleukin-1 augments release of norepinephrine, dopamine and serotonin in the rat anterior hypothalamus, J. Neurosci., 13, 3574-3581.
  11. Schmidt, E.D., Janszen, A.W.J.W., Wouterlood, F.G. and Tilders, F.J.H. (1995). Interleukin-1 induced long-lasting changes in hypothalamic corticotropin-releasing hormone (CRH) neurons and hyperresponsiveness of the hypothalamic-pituitary-adrenal axis. J. Neurosci., 15, 7417-7426.
  12. Tilders, F.J.H., Schmidt, E.D. and De Goeij D.C.E. (1993) Phenotypic plasticity of CRF neurons during stress. Ann. N. Y. Acad. Sci. 697, 39-52.
  13. Uomoto M., Nishibori M, Nakaya N, Takeuchi Y, Iwagaki H, Tanka N and Saeki K. (1998). Changes in monoamine turnover in the brain of cachectic mice bearing colon-26 tumor cells. J. Neurochem., 70, 260-267.
  14. Warren E.J., Finck B.N., Arkins S., Kelley K.W., Scamurra R.M., Murtaugh M.P. and Johnson R.W. (1997). Coincidental changes in behavior and plasma cortisol in unrestrained pigs after intracerebroventricular injection of tumor necrosis factor-. Endocrinology, 138, 2365-2371.

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<= Discussion & Conclussions REFERENCES

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Hayley, S; Brebner, K; Merali, Z; Anisman, H; (1998). Sensitization Effects of TNF-alpha: Behavioral and Neurochemical Processes. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/anisman/hayley0615/index.html
© 1998 Author(s) Hold Copyright