Invited Symposium: Cytokines, Monoamines and Behavior



Materials & Methods


Discussion & Conclusion



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Sensitization Effects of TNF-alpha: Behavioral and Neurochemical Processes

Contact Person: Shawn Hayley (shayley@ccs.carleton.ca)

Discussion and Conclusion

It is clear that systemic administration of TNF-a not only elicits behavioral and neuroendocrine consequences, but also has pronounced central neurochemical effects. It remain to be established whether these are a direct effect of the cytokine treatment or secondary to the malaise engendered by the a TNF-a. Whatever the case it appeared that the neuroendocrine and central neurochemical effects of the cytokine were subject to a time-dependent sensitization. In particular, HPA activity, as reflected by levels of circulating corticosterone, may be enhanced when TNF-a reexposure occurs 14-28 days after initial treatment, but suppressed when reexposure occurs 24 h after initial administration. Of particular interest was the finding that the sensitization of noradrenergic utilization within the PVN essentially paralled the corticoid and behavioral changes, whereas a distinct sensitization was evident after a much earlier time interval (24 h) in the PFC. These findings have potentially important implications for immunotherapy, just as the effects of IL-1 are pertinent in this respect. For instance, some of the psychiatric disturbances seen in patients receiving immunotherapy (e.g., after IL-2) may be related to alterations in CNS neurotransmitter activity, particularly when the therapeutic regimen involves repeated administration of the cytokine.

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Hayley, S; Brebner, K; Merali, Z; Anisman, H; (1998). Sensitization Effects of TNF-alpha: Behavioral and Neurochemical Processes. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/anisman/hayley0615/index.html
© 1998 Author(s) Hold Copyright