Invited Symposium: Stroke/Cerebral Vasospasm



Materials & Methods


Discussion & Conclusion



INABIS '98 Home Page Your Session Symposia & Poster Sessions Plenary Sessions Exhibitors' Foyer Personal Itinerary New Search

Tyrosine Kinase In Cerebral Vasospasm

Contact Person: S. Iwabuchi, MD, PhD (iwabuchi@med.toho-u.ac.jp)


  1. Kiwak KJ, Heros RC (1987) Cerebral vasospasm after subarachnoid hemorrhage. Trends Neurol Sci, 10: 89-92.
  2. Kassell NF, Torner JC, Haley EC Jr, Jane JA, Adams HP, Kongable GL (1990) The international cooperative study on the timing of aneurysm surgery. Part 1: Overall management results. J Neurosurg, 73: 18-36.
  3. Tanishima T, Asano T, Sasaki T, et al (1979) Role of peroxidation in the genesis of cerebral arterial spasm. Acta Neurol Scand 60 (suppl 72), 484-485.
  4. Toda N, Shimizu K, Ohta T (1980) Mechanism of cerebral arterial contraction induced by blood constituents. J Neurosurg, 53: 312-322.
  5. Nosko M, Krueger CA, Weir BKA, et al (1986) Effects of nimodipine on in vivo contractility of cerebral arteries of dog, monkey and man. J Neurosurg, 65: 376-381.
  6. Dora E, Feher E, Farago M, et al (1989) Mechanism of hemoglobin-induced spasm in the isolated middle cerebral artery of the cat. Adv Exp Med Biol, 248: 533-542.
  7. Vollrath BAM, Weir BKA, Macdonald RL, et al (1994) Intracellular mechanisms involved in the responses of cerebrovascular smooth-muscle cells to hemoglobin. J Neurosurg, 80: 261-268.
  8. Zucearello M, Boccaletti R, Tosun M, et al (1996) Role of extracellular Ca2+ in subarachnoid hemorrhagic-induced spasm of the rabbit basilar artery. Stroke, 27: 1896-1902.
  9. Lee TJ-F, Mcllhaney MP, Sarwinski SJ (1984) Erythrocyte extracts enhance neurogenic vasoconstriction of dog cerebral arteries in vitro. J Cereb Blood Flow Metab, 4: 474-476.
  10. Linnik MD, Lee TJ-F (1989) Effect of hemoglobin on neurogenic responses and cholinergic parameter in porcine cerebral arteries. J Cereb Blood Flow Metab, 9: 219-225.
  11. Edwards DH, Byrne JV Griffith TM (1992) The effect of chronic subarachnoid hemorrhage on basal endothelium-derived relaxing factor activity in intrathecal cerebral arteries. J Neurosurg, 76: 830-837.
  12. Aoki T, Takenaka K, Suzuki S, et al (1994) The role of hemolysate in the facilitation of oxyhemoglobin-induced contraction of rabbit basilar arteries. J Neurosurg, 81: 261-266.
  13. Zhang H, Weir B, Marton LS, et al (1995) Mechanisms of hemolysate-induced [Ca2+]i elevation in cerebral smooth muscle cells. Am J Physiol, 269 (Heart Circ Physiol 38): H1874-H1890.
  14. Hollenberg MD (1994) Tyrosine kinase pathways and the regulation of smooth muscle contractility. Trends Pharmacol Sci, 15: 108-114.
  15. Di Salvo J, Kaplan N, Semenchuk LA (1996) Protein tyrosine phosphorylation and regulation of intracellular calcium in smooth muscle cells, in Barany M (ed): Biochemistry of Smooth Muscle Contraction. San Diego: Academic Press, pp 283-293.
  16. Marton LS, Weir BKA, Zhang H (1996) Tyrosine phosphorylation and [Ca2+]i elevation induced by hemolysate in bovine endothelial cells: implications for cerebral vasospasm. Neurol Res, 18: 349-353.
  17. Minetti M, Mallozzi C, Scorza G, et al (1993) Role of oxygen and carbon radicals in hemoglobin oxidation. Arch Biochem Biophys, 302: 233-244.
  18. Grynkiewicz G, Poenie M, Tsien R (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem, 260: 3440-3450.
  19. Zhang H, Weir B, Macdonald RL, et al (1996) Mechanisms of [Ca2+]i elevation induced by erythrocyte components in endothelial cells. J Pharmacol Exp Ther, 277: 1501-1509.
  20. Abler A, Smith JA, Randazzo PA, et al (1994) Genistein differentially inhibits postreceptor effects of insulin in rat adipocytes without inhibiting the insulin receptor kinase. J Biol Chem, 267: 3946-3951.
  21. Levitzki A, Gilon C (1991) Tyrphostins as molecular tools and potential antiproliferative drugs. Trends Pharmacol Sci, 12: 171-174.
  22. Jayaraman T, Ondrias K, Ondriasova E, et al (1996) Regulation of the inositol 1,4,5- trisphospate receptor by tyrosine phosphorylation. Science, 272: 1492-1494.
  23. Glenney JR Jr (1992) Tyrosine-phosphorylated proteins: mediators of signal transduction from the tyrosine kinases. Biochem Biophys Acta, 1134: 113-127.
  24. Umemori H, Inoue T, Kume S, Sekiyama N, Nagao M, Itoh H, Nakanishi S, Mikoshiba K, Yamamoto T (1997) Activation of the G protein Gq/11 through tyrosine phosphorylation of the subunit. Science, 276: 1878-1881.
  25. Sargeant P, Farndale RW, Sage SO (1993) ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. J Biol Chem, 268: 18151-18156.
  26. Lee K-M, Toscas K, Villereal ML (1993) Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors. J Biol Chem, 268: 9945-9948.
  27. Macdonald RL, Weir BKA (1991) A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke, 22: 971-982.
  28. Sima B, Macdonald RL, Marton LS, et al (1996) Effect of P2-purinoceptor antagonists on hemolysate-and ATP-induced contractions of dog basilar artery in vitro. Neurosurgery, 39: 815-822.
  29. Kim CJ, Kim KW, Park JW, Lee JC, Zhang JH (1998) Role of tyrosine kinase in erythrocyte lysate-induced contraction in rabbit cerebral arteries. J Neurosurg, 89: 289-296.

Back to the top.

<= Discussion & Conclussions REFERENCES

| Discussion Board | Next Page | Your Symposium |
Iwabuchi, S MD; Zhang, J MD PhD.; Aoki, K MD.; Marton, L PhD.; Kimura, H MD.; Samejima, H MD; (1998). Tyrosine Kinase In Cerebral Vasospasm. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/zhang/iwabuchi0452/index.html
© 1998 Author(s) Hold Copyright