Invited Symposium: SERCA-Type of Calcium Pumps and Phospholamban


SERCA pumps


Protein Kinase Regulation




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An Overview of SERCA Classes and Their Regulation

Grover, AK. (Department of Medicine, McMaster University, Canada)
Mack, D. (Department of Medicine, McMaster University, Canada)
Misquitta, CM. (Department of Medicine, McMaster University, Canada)

Contact Person: Ashok K. Grover (groverak@fhs.mcmaster.ca)


SERCA pumps sequester Ca2+ into the sarco/endoplasmic reticulum and from there it is released during signal transduction. The uptake occurs with a stoichiometry of 2 Ca2+ per ATP hydrolyzed. SERCA proteins are encoded by three genes (SERCA1, 2 and 3) located on separate chromosomes. SERCA transcripts are expressed and alternatively spliced in a tissue dependent manner. The resulting mRNA species encode different SERCA protein isoforms and differ in 3'-untranslated regions (UTR). SERCA protein isoforms differ in their Ca2+ affinity, resistance to oxidative stress and modulation by sarcolipin, phospholamban, and Ca2+/calmodulin kinase II . This poster will summarize this information and then analyze it by posing the following questions. How does Ca2+ affinity of the pump affect tissue function? Do some tissues need more oxidation resistant SERCA isoforms than others? What is the importance of a phospholamban binding site in SERCA1 and 2 but not in 3? Do the isoforms differ in their localization with respect to Ca2+ release channels, agonist induced Ca2+-entry and/or Ca2+ binding proteins? Does the SERCA pump isoform expression relate to properties of Ca2+ wave forms produced upon cell activation? - Supported by Medical Research of Canada and Heart & Stroke Foundation of Ontario.

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Presentation Number SAgrover0312
Keywords: ATPase, Calcium, Ca2+ release, regulation, isoforms

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Grover, AK.; Mack, D.; Misquitta, CM.; (1998). An Overview of SERCA Classes and Their Regulation. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/wuytack/grover0312/index.html
© 1998 Author(s) Hold Copyright