Occupational Health - Public Health Poster Session
Free fatty acids (FFA) released from milk fat globules by the action of breast-milk lipases has been recognized as being responsible for the cytolytic effect observed in human breast-milk that was stored over a period of a few days. The cytolytic effect of milk FFA was previously shown to kill intestinal parasites-Giardia lamblia and Entamoeba histolytica, as well as causing a membrane disruption of enveloped viruses in cultured cells. It has also been shown to possess cytolytic effects on normal white and red blood cells. The cis-unsaturated FFA are the main mediators of this cytolytic effect, with less contributions by lyso-phosphatidylcholine and mono-glycerides, but not di-glycerides, phosphatidylcholine, triolein or glycerol. Lipolysis-induced hemolysis (LIH) has been presently characterized, using sheep red blood cells a s targets. LIH was found to be temperature-dependent, greatly enhanced by low concentrations of magnesium ions and inhibited by moderate to excess amounts of calcium ions.
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|Ogundele, M.O.; (1998). CHARACTERIZATION OF LIPOLYSIS-INDUCED TOXICITY BY STORED HUMAN BREAST-MILK. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/occupational/ogundele0297/index.html|
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