Occupational Health - Public Health Poster Session
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Abstract
Free fatty acids (FFA) released from milk fat globules by the action of breast-milk lipases has been recognized as being responsible for the cytolytic effect observed in human breast-milk that was stored over a period of a few days. The cytolytic effect of milk FFA was previously shown to kill intestinal parasites-Giardia lamblia and Entamoeba histolytica, as well as causing a membrane disruption of enveloped viruses in cultured cells. It has also been shown to possess cytolytic effects on normal white and red blood cells. The cis-unsaturated FFA are the main mediators of this cytolytic effect, with less contributions by lyso-phosphatidylcholine and mono-glycerides, but not di-glycerides, phosphatidylcholine, triolein or glycerol. Lipolysis-induced hemolysis (LIH) has been presently characterized, using sheep red blood cells a s targets. LIH was found to be temperature-dependent, greatly enhanced by low concentrations of magnesium ions and inhibited by moderate to excess amounts of calcium ions.
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Poster Number PAogundele0297
Keywords: human milk, toxicity, pH, calcium, magnesium
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