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New Technology Poster Session






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
Board

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The Role of FDG-PET in Diagnosing Suspected Tumor Recurrence Based on Increassed Levels of Plasma Markers


Contact Person: A. Maldonado Suárez (Centro.pet@telprof.omc.es)


Introduction

To evaluate the usefulness of Positron Emission Tomography with 18F-Fluordeoxyglucose (FDG-PET) to detect tumor recurrence on the basis of tumor marker increases, where negative results have been obtained with conventional methods (TC,RM,MN).

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Materials and Methods

Whole-body FDG-PET was performed on 72 cancer patients: 23 with breast cancer, 18 colorectal cancer, 15 thyroid cancer, 6 lung cancer, 3 ovarian neoplasms and 7 other tumors. In all tumors, tumor recurrence was suspected on the basis of marker increases, and negative results had been obtained with conventional studies.

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Results

FDG-PET detected lesions in 85% of the patients, which were confirmed in 33%. In 40% of all cases, therapeutic treatments were applied, and in 14% curative surgery was perfomed. Results are shown in the next table:

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TYPE OF      N     Study     Total     Confirmed  Patients whose   Patients who
TUMOR             FDG-PET(+) PET-FDG   PET-FDG    Treatments were  underwent surgery
                             Lesions   Lesions    Changed          for curative purposes
----------------------------------------------------------------------------------------         
Breast       23     18        63        26         8                  0
Colo-Rectal  18     17        34        11         9                  5
Thyroid      15     12        34        14         5                  4                         
Lung          6      6        21         0         0                  0
Ovary         3      3         6         3         1                  1
Other         7      5         8         1         6                  0
TOTAL        72    61/72     166      55/166      29/72              10/72
                    85%                33%         40%                14%
----------------------------------------------------------------------------------------

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Discussion and Conclusion

Whole-body PET-FDG is a useful procedure in the diagnosis of recurring tumoral disease in patients with rising tumor marker levels, where negative results had been obtained with convencional methods.

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Maldonado, A.; Ortega, F.; Gorospe, E.; Melgarejo, M.; Ruiz, JA.; Kosvintseva, O.; Trampal, C.; (1998). The Role of FDG-PET in Diagnosing Suspected Tumor Recurrence Based on IncreassedLlevels of Plasma Markers. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/newtech/maldonado0495/index.html
© 1998 Author(s) Hold Copyright