Neuropharmacology Poster Session
Epilepsy is a class of disorders characterized by seizures attributable to abnormal, synchronous neural activity in the brain. While the underlying etiology of epilepsy is usually unknown, much work has been devoted to the prevention or control of seizure activity. Currently, pharmacological intervention is the most effective and prevalent strategy for the treatment of epilepsy. While there has been a plethora of research conducted on the efficacy of anticonvulsant compounds, many of the side effects due to maintenance on these drugs have not been adequately investigated. One such side effect involves the reported impairment in mental processing associated with antiepileptic drug treatment. It has been repeatedly suggested that while seizure activity can profoundly impair learning abilities, maintenance on anticonvulsant drugs themselves can potentiate these impairments. In agreement with these suggestions, we have previously reported learning impairments in rats and rabbits in instrumental and Pavlovian conditioning tasks respectively (e.g., Churchill et al., 1998).
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|Churchill, JD; Herron, AH; Fang, P-C; Voss, SE; Garraghty, PE; (1998). The Effects of the Antiepileptics Phenytoin, Carbamazepine, Valproic Acid and Ethosuximide on Rats Learning a Water Maze Task. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuropharm/churchill0693/index.html|
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