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Invited Symposium: Hypertension I: Structure of Small Arteries in Hypertension






Abstract

Introduction

Materials & Methods

Results

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Inward Hypertrophic Remodelling in Subcutaneous Small Arteries of Patients with Renovascular Hypertension, but Not with Primary Aldosteronism.

Rizzoni, D (UOP Scienze Mediche University of Brescia c/o 1a Medicina Spedali Civili, 25100 Brescia, Italy)
Porteri, E (UOP Scienze Mediche University of Brescia c/o 1a Medicina Spedali Civili, 25100 Brescia, Italy)
Piccoli, A (UOP Scienze Mediche University of Brescia c/o 1a Medicina Spedali Civili, 25100 Brescia, Italy)
Castellano, M (UOP Scienze Mediche University of Brescia c/o 1a Medicina Spedali Civili, 25100 Brescia, Italy)
Bettoni, G (UOP Scienze Mediche University of Brescia c/o 1a Medicina Spedali Civili, 25100 Brescia, Italy)
Pasini, G (UOP Scienze Mediche University of Brescia c/o 1a Medicina Spedali Civili, 25100 Brescia, Italy)
Mulvany, MJ (University of Aarhus, Department of Pharmacology, Aarhus, Denmark)
Agabiti Rosei, E (UOP Scienze Mediche University of Brescia c/o 1a Medicina Spedali Civili, 25100 Brescia, Italy)

Contact Person: Damiano Rizzoni (rizzoni@master.cci.unibs.it)


Abstract

Vascular structural alterations in small resistance arteries of patients with essential hypertension are mostly characterized by inward eutrophic remodelling. However, experimental models of hypertension with high circulating renin are characterized by the presence of smooth muscle cell hypertrophy. The aim of our study was to investigate at the cellular level the structural characteristics of subcutaneous small resistance arteries in patients withprimary or secondary forms of hypertension, using 'the disector'. Fifteen patients with renovascular hypertension (RVH), 8 with primary aldosteronism, 13 with essential hypertension and 9 normotensive subjects have been included in the study. A biopsy of subcutaneous fat was taken from all subjects. Small arteries were dissected and mounted on a micromyograph and the media/lumen ratio (M/L) was calculated. The cell volume (CV) and the number of cell per segment length (NC). The M/L and the CV was significantly greater in RVH compared with the other groups. No difference in NC was observed between groups. In conclusion, an inward hypertrophic remodelling, as evaluated by a direct, unbiased method, was observed only in small resistance arteries of RVH. Therefore, for the first time our data demonstrated that a pronounced activation of the renin-angiotensin-aldosterone system is associated to vascular smooth muscle cell hypertrophy also in human hypertension.

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Presentation Number SArizzoni0293
Keywords: vascular structur, hypertrophy, hypertension, remodelling


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Rizzoni, D; Porteri, E; Piccoli, A; Castellano, M; Bettoni, G; Pasini, G; Mulvany, MJ; Agabiti, R.E; (1998). Inward Hypertrophic Remodelling in Subcutaneous Small Arteries of Patients with Renovascular Hypertension, but Not with Primary Aldosteronism.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/mulvany/rizzoni0293/index.html
© 1998 Author(s) Hold Copyright