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Differential Vascular Effects of Panax Ginseng and Panax Quinquefolius Extracts

Contact Person: C. Y. Kwan (kwancy@fhs.mcmaster.ca)


  1. Chen X, Gillis CN, Moalli R, 1984; Vascular effects of ginsenosides in vitro. Br J Pharmacol 82: 485-491.
  2. Deng HW, Guan YY, Kwan CY, 1990; The effects of ginsenosides on lipid peroxidation in liver and cardiac muscle homogenates. Biochem Arch 6: 359-365.
  3. Gillis CN, Panax ginseng pharmacology: a nitric oxide link? Biochem Pharmacol 1997; 54: 1-8.
  4. Guan YY, He H, Chen JX, 1985; Effect of the total saponins of Panax notoginseng on contraction of rabbit aortic strips. Acta Pharmacol Sinica 6: 267-269.
  5. Guan YY, Kwan CY, Daniel EE, 1988; Inhibition of norepinephrine-induced contractile responses of canine mesenteric artery by plant total saponins. Blood Vessels 25: 312-315.
  6. Guan YY. Kwan CY, He H, Sun JJ, Daniel EE, 1994; Effects of Panax notoginseng saponins on receptor-operated Ca2+ channels in vascular smooth muscle. Acta Pharmacol Sinica 15: 392-398.
  7. Jackson CV, Mickelson Jk, Pope TK, Rao TK, Lucchesi BR, 1986; Oxygen free radical-mediated myocardial and vascular dysfunction. Am J Physiol 251: H1225-H1231.
  8. Jiang XY, Zhang JT, Shi CZ, 1996; Mechanism of action of ginsenoside Rb1 in decreasing intracellular Ca2+. Acta Pharm Sinica 31: 321-326.
  9. Kang SY, Schini-Kerth VB, Kim ND. 1995; Ginsenosides of the proptopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Lif Sci 56: 1577-1586.
  10. Kim H, Chen X, Gillis CN, 1992: Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochem Biophys Res Commun 189: 670-676.
  11. Kimura Y, Okuda, Arichi S, 1988; Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets. J Pharm Pharmacol 40: 838-843.
  12. Kravtsov GM, Kwan CY, 1995a;A revisitation of the mechanism of action of KCl-induced vascular smooth muscle contraction: a key role of cation biding to the plasma membrane. Biol Signals 4: 160-167.
  13. Kravtsov GM, Kwan CY, 1995b; Regulation of vascular contraction by ionic matric surfaces of the smooth muscle cells: Changes in SHR? Clin Exp Pharmacol Physiol 22 (suppl 1): S297-S299.
  14. Kwan CY, Guan YY, Deng HW, 1995; Calcium antagonistic and antioxidant effects of ginseng saponins. In: Proceedings of the International Ginseng Conference (eds, Bailey WB, Whitehead C, Proctor JTA, Kyl JT), Simon Fraser University, Burnaby. pp. 318-323.
  15. Liberti L, Marderosian AD, 1978; Evaluation of commercial ginseng products. J Pharm Sci 67: 1487-1489.
  16. Soldati F, Sticher O. 1980; HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. Planta Med 39: 348-357.
  17. Tanaka O, Kasai R, Morita T, 1986; Chemistry of ginseng and related plants: recent advances. Abstr Chin Med 1: 130-152.
  18. Teng CM, Kuo SC, Ko FN, Lee JC, Lee LG, Chen SC, Huang TF, 1989; Antiplatet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophs Acta 990: 315-320.
  19. Wu J, Yu XJ, Liu CH, 1995; Effects of saponins of Panax quinquefolium leaf and stem on isolated rabbit aortic strips. Chin J Pharmacol Toxicol 9: 155-156.
  20. Xiong ZG, Sun JJ, 1989; Effects of Panax notoginseng saponin Rb1 and Rg1 on myocardial action potential and slow inward current. Acta Pharmacol Sinica 10: 520-522.
  21. Zhan Y Xu XH, Jiang YP, 1994; Effects of ginsenosides on myocardial ischemia/reperfusion damage in open-heart surgery patients. Med J China 74: 626-628.
  22. Zhang D, Yasuda T, Yu Y, Zhen P, Kawabata T, Ma Y, Okada S, 1996; Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation. Free Radic Biol Med 20: 145-150.
  23. Zhang WJ, Zhong GG, Jiang Y, Wang XM, Wang ZF, 1994; Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Acta Pharmacol Sinica 15: 173-176.
  24. Zhang YG, Liu TP, 1994: Protective effects of total saponins of P. ginseng on ischemia-reperfusion injury in rat brains. Chin J Pharmacol Toxicol 8: 7-12.

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<= Discussion & Conclussions REFERENCES

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Kwan, CY; (1998). Differential Vascular Effects of Panax Ginseng and Panax Quinquefolius Extracts. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/kwan/kwan0249/index.html
© 1998 Author(s) Hold Copyright