Invited Symposium: Medicinal Plants and Drug Actions
PURPOSE: To study and copare the vascular effects of the commercial sources of extracts prepared from the root of Panax ginseng (G-115) and the leaf and stem of Panax quinquefolius (PQS). METHODS: Isometric contractile responses were investigated using de-endothelialized rings of dog carotid artery (DCA) and rat aorta (RAO). RESULTS: G-115 (0.6 mg/ml) inhibited the myogenic tone in the aorta of spontaneously hypertensive rats (SHR) and had no effect on the basal tension of the aorta of the Wistar/Kyoto normotensive control rats (WKY). G-115 also inhibited the RAO contraction induced by NaCl or phenylephrine (PE) but not that induced by KCl. However, PQS (0.5 mg/ml) was found to inhibit KCl-induced contraction in DCA rings much more prominently than that induced by PE. DISCUSSION: The vascular effects of G-115 appeared to be very similar to those obtained with the total saponins extracted from Panax notoginseng (PNS)in that it inhibits PE-induced contraction, but not KCl-induced contraction. We have previously reported that the total ginsenosides isolated from the root of Panax quinquefolius, unlike PNS, G-115 or PQS, enhanced the contractile responses of dog mesenteric artery to suboptimal concentration of PE. CONCLUSION: Differential vascular effects were observed in ginseng extracts obtained from different ginseng products and may be due to the different gensenoside compositions in these products.
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|Kwan, CY; (1998). Differential Vascular Effects of Panax Ginseng and Panax Quinquefolius Extracts. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/kwan/kwan0249/index.html|
|© 1998 Author(s) Hold Copyright|