|  Immunology & Immunological Disorders Poster Session
 
 
 
 
 
 
   Abstract 
   Introduction 
   Materials & Methods 
   Results 
   Discussion & Conclusion 
   References 
 
 
 
   DiscussionBoard
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Induction of Th1-type cytokines in vitro by lipoteichoic acid-related  molecule isolated from OK-432, a streptococcal preparation. 
 Contact Person: Masato Okamoto (mokamoto@dent.tokushima-u.ac.jp)
 
 References
 
 
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Ono T, Kurata S, Wakabayashi K, Sugawara Y, Saito M, Ogawa H (1973) Inhibitory effect of a streptococcal preparation (OK-432) on the nucleic acid synthesis in tumor cells in vitro. Jpn J Cancer Res., 64:59-69.
Sakurai Y, Tsukagoshi S, Satoh H, Akiba T, Suzuki S, Takagaki Y (1972) Tumor-inhibitory effect of a streptococcal preparation (NSC-B116209). Cancer Chemother Rep., 56:9-17.
Okamoto H, Shoin S, Koshimura S (1978) Streptolysin S-forming and anticancer activities of group A streptococci. In: Jeljaszewicz J, Wadstrom T, eds. Bacterial toxin and cell membranes. New York: Academic Press, 259-89.
Kimura I, Ohnishi Y, Yasuhara S, Watanabe T, Sugiyama M, Kiraki K (1974) Studies on the host-mediated action of the streptococcal preparation, OK-432, in cancer chemotherapy. Acta Med Okayama, 28:423-31.
Ishii Y, Yamaoka H, Toh K, Kikuchi K (1976) Inhibition of tumor growth in vivo and in vitro by macrophages from rats treated with a streptococcal preparation, OK-432. Jpn J Cancer Res., 67:115-9.
Oshimi K, Kano S, Takaku F, Okumura K (1980) Augmentation of mouse natural killer cell activity by a streptococcal preparation, OK-432. J Natl Cancer Inst., 65:1265-9.
Oshimi K, Wakasugi H, Seki H, Kano S (1980) Streptococcal preparation, OK-432 augments cytotoxic activity against an erythroleukemic cell line in humans. Cancer Immunol Immunother., 9:187-92.
Matsubara S, Suzuki F, Ishida N (1979) Induction of immune interferon in mice treated with a bacterial immunopotentiator, OK-432. Cancer Immunol Immunother., 6:41-5.
Ebina T, Sakai A, Saito M (1981) Interferon induction and augmentation of natural killer cell activity by immunopotentiators (in Japanese). Igakunoayumi, 117:229-34.
Sato M, Yoshida H, Yanagawa T (1984) Effects of intradermal administration of streptococcal preparation OK-432 on interferon and natural killer cell activities in patients with oral cancer. Int J Oral Surg., 13:7-15.
Hoshino T, Iho S, Kura F, Uchida A (1986) In vivo and in vitro biological effects of OK-432, a streptococcal preparation, on the augmentation of autologous tumor cell killing activity and cytokine production of lymphocytes and monocytes in malignant deseases. In: Micksche M, Klein E, eds. OK-432. A biological response modifier. Tokyo: Professional Postgraduate Services, International, 61-8.
Nagamuta M, Yamamoto A, Usami Y (1986) Induction of TNF in peritoneal fluid of mice treated with OK-432. In: Ishida N, ed. Mechanisms of antitumor effects of OK-432. Tokyo: Excerpta Medica, 126-36.
Djeu JY, Heinbaugh JA, Holden HT, Herberman RB (1979) Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J Immunol., 122:175-81.
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Peri G, Polentaruti N, Sessa C, Mangioni C, Mantovani A (1981) Tumoricidal activity of macrophages isolated from human ascitic and solid ovarian carcinomas: augmentation by interferon, lymphokine and endotoxin. Int J Cancer, 28:143-52.
Yanagawa E, Toge T, Niimoto M, Hattori T (1986) In vitro augmentation of natural and autotumor killing activity of tumor-associated macrophages by OK-432, interleukin-2, and interferon. In: Hoshino T, ed. Immunopharmacological aspects of OK-432 in humans. Tokyo: Excerpta Medica,17-26.
Gidlund M, Orn A, Wigzell H, Senik A, Gresser I (1978) Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature (Lond), 273:759-61.
Schultz RM, Papamatheakis ID, Chirigos MA (1978) Functional and morphologic characteristics of interferon-treated macrophages. Cell Immunol.,35:84-91.
Okamoto M, Kaji R, Kasetani H, Yoshida H, Moriya Y, Saito M, Sato M (1993) Purification and characterization of interferon-g-inducing molecule of OK-432, a penicillin-killed streptococcal preparation, by monoclonal antibody neutralizing interferon-g-inducing activity of OK-432. J Immunother., 13:232-42.
 
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