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Induction of Th1-type cytokines in vitro by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal preparation.

Contact Person: Masato Okamoto (mokamoto@dent.tokushima-u.ac.jp)


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  6. Ishii Y, Yamaoka H, Toh K, Kikuchi K (1976) Inhibition of tumor growth in vivo and in vitro by macrophages from rats treated with a streptococcal preparation, OK-432. Jpn J Cancer Res., 67:115-9.
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  12. Hoshino T, Iho S, Kura F, Uchida A (1986) In vivo and in vitro biological effects of OK-432, a streptococcal preparation, on the augmentation of autologous tumor cell killing activity and cytokine production of lymphocytes and monocytes in malignant deseases. In: Micksche M, Klein E, eds. OK-432. A biological response modifier. Tokyo: Professional Postgraduate Services, International, 61-8.
  13. Nagamuta M, Yamamoto A, Usami Y (1986) Induction of TNF in peritoneal fluid of mice treated with OK-432. In: Ishida N, ed. Mechanisms of antitumor effects of OK-432. Tokyo: Excerpta Medica, 126-36.
  14. Djeu JY, Heinbaugh JA, Holden HT, Herberman RB (1979) Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J Immunol., 122:175-81.
  15. Herberman RB, Ortaldo JR, Mantovani A, Hobbs DS, Kung HF, Pestka S (1982) Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol., 67:160-7.
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  17. Yanagawa E, Toge T, Niimoto M, Hattori T (1986) In vitro augmentation of natural and autotumor killing activity of tumor-associated macrophages by OK-432, interleukin-2, and interferon. In: Hoshino T, ed. Immunopharmacological aspects of OK-432 in humans. Tokyo: Excerpta Medica,17-26.
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  20. Okamoto M, Kaji R, Kasetani H, Yoshida H, Moriya Y, Saito M, Sato M (1993) Purification and characterization of interferon-g-inducing molecule of OK-432, a penicillin-killed streptococcal preparation, by monoclonal antibody neutralizing interferon-g-inducing activity of OK-432. J Immunother., 13:232-42.

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Okamoto, M.; Goda, H.; Ohe, G.; Yoshida, H.; Sato, M.; (1998). Induction of Th1-type cytokines in vitro by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal preparation.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/immunology/okamoto0234/index.html
© 1998 Author(s) Hold Copyright