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Insulinoma of Pancreas. Report one case Analysis clinical and ultrastructural.

Contact Person: Alberto G Pizarro (rediegal@homonet.com.mx)


In 1924 Searle Harris postulated spontaneous hypoglycemia could be caused by the excessive secretion of insulin. (1) Over more 2000 cases of insulinoma now have been recorded in the literature. The Insulinoma possess the capacity of synthesize, package, and realease insulin into the blood. Insulinomas are more likely to be benign than malignant. Only 10% are multiples and only 10% are malignant; 10% are associated with MEN-1. The clinical manifestations are hypoglycemia, which is produced by an inappropriate secretion of insulin by the tumor. These tumors may occur alone or as part of a MEN syndrome. Fasting hypoglycemia (<40 mg/dL) associated with an elevated insulin level (in the absence of exogenous administration of insulin) is pathognomonic. (2)

Tumor composed of islet cell tissue occasionally occur in the pancreas, most frequently in the body and tail of the organ. They are usually small, less than 2 cm diameter, and only rare examples have measured up to 6 cm diameter. They usually appear well circumscribed, and some have a fibrous capsule. The benign insulin-producing islet cell adenomas usually are circumscribed or encapsulated. In some cases, there seems to be microscopic evidence of invasion, but no metastases are present, and there is a clinically benign course. (2,3)

The arrangement of the tumor cells in anastomosing cord, the concentration of the argyrophil granules toward the peripheri of the tumor cell cords and increased insulin are diagnosis of insulinoma. (3)

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Pizarro, A; Díaz, R; (1998). Insulinoma of Pancreas. Report one case Analysis clinical and ultrastructural.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/cancer/pizarro0149/index.html
© 1998 Author(s) Hold Copyright