Behavioural Neuroscience Poster Session
Venerosi, A. (Section Comp Psychol, Organ and System Pathophysiol Lab, Ist. Sup. Sanita, Italy)
Calamandrei, G. (Section Comp Psychol, Organ and System Pathophysiol Lab, Ist. Sup. Sanita, Italy)
Alleva, E. (Section Behav Pathophysiol, Organ and System Pathophysiol Lab, Ist. Sup. Sanita, Italy)
Since 1993 AZT treatment of seropositive pregnant women and puerperae has been widely used due to its effectivness in reducing risks of mother/newborn transmission of HIV. Medium- and long-term effects of AZT on neurobehavioural development and adult responding are still poorly described, even though some limited, selective, and sex-dependent alterations have been already reported in rodent models of human exposure. Aim of the present study was to evaluate the long-term effects of prenatal AZT treatment on aggressive behaviour of adult male mice. Pregnant CD-1 mice were administered saline vehicle, 0.4, or 0.8 mg/ml AZT in drinking water from gestation day 10 to delivery. Social-aggressive types of interaction were assessed in their male offspring (10 mice from each treatment group) following a 4-week isolation period according to two tasks: a single 20-min encounter with an isolated same-strain opponent on postnatal day (PND) 90, or five repeated pairings with a group-caged opponent (maintained in 8-male groups) on PND 150. Dose dependent alteration of both aggressive and defensive components of the male-specific agonistic pattern was evident only in the former test, AZT mice showing 'dominant-type' features more often than corresponding controls. This work was supported by IX Project on AIDS of the Italian Ministry of Health (grants no. 940-A and 10/A/G).
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|Rondinini, C.; Venerosi, A.; Calamandrei, G.; Alleva, E.; (1998). LONG TERM EFFECTS OF PRENATAL 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) EXPOSURE ON INTERMALE AGGRESSIVE BEHAVIOUR OF MICE. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/behavneuro/rondinini0231/index.html|
|© 1998 Author(s) Hold Copyright|