Surgery and Orthopedics Poster Session
Liebmann, P.M. (Institute of General & Experimental Pathology, University of Graz, Austria)
Stoschitzky, K. (Deptartment of Internal Medicine, Division of Cardiology, University of Graz, Austria)
Lercher, P. (Deptartment of Internal Medicine, Division of Cardiology, University of Graz, Austria)
Schauenstein, K. (Institute of General & Experimental Pathology, University of Graz, Austria)
Klein, W. (Deptartment of Internal Medicine, Division of Cardiology, University of Graz, Austria)
Eber, B. (II. Medical Deptartment, General Hospital Wels, Austria)
Aims: Decreased night-time plasma levels of melatonin were recently reported in patients with coronary artery disease (CAD), and it was postulated that melatonin production may be impaired, due to a lack of synthesising enzymes. However, since artefacts possibly influencing the release pattern were not taken into account, this interpretation was strongly criticised. We therefore carefully reinvestigated night-time melatonin production in patients with CAD using an appropriate experimental approach. Furthermore, we examined the effect of b-blockers, a frequently used drug in CAD therapy. Methods and Results: Fourty-eight male patients with angiographically documented severe CAD, 24 of them taking b-blockers daily in therapeutical dosages, were included. Eighteen age-matched men, who did not show atherosclerotic changes in coronary angiography, served as controls. For determination of melatonin production, 6-sulfatoxymelatonin (aMT6s) was measured radioimmunologically in the overnight urine. Urinary aMT6s concentration was highly significantly decreased in patients, and b-blocker treatment did not further suppress melatonin production. Conclusions: The data obtained using this investigative approach provide clearcut evidence that melatonin production in patients with CAD is decreased. Whether a decreased melatonin level may be a predisposing factor to CAD, or whether the occurrence of CAD decreases melatonin synthesis remains to be determined.
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|Sakotnik, A.; Liebmann, P.M.; Stoschitzky, K.; Lercher, P.; Schauenstein, K.; Klein, W.; Eber, B.; (1998). Decreased Melatonin Synthesis in Patients with Coronary Artery Disease. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/surgeryortho/sakotnik0670/index.html|
|© 1998 Author(s) Hold Copyright|