Invited Symposium: Molecular and Cellular Analysis of Dopamine and Serotonin Transporters





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Neurotransmitter Transporters Are NOT in the Synapse?

Kuhar, M (Division of Neuroscience, Yerkes Primate Center, Emory University, USA)

Contact Person: Michael J Kuhar (mkuhar@rmy.emory.edu)


Electron microscopic immunhistochemistry suggests that at least some transporters are not found IN the synapse, but rather AROUND or in perisynaptic parts of the axonal and nerve terminal membrane. Other anatomical and physiologic findings support this for some transporters such as the one for dopamine. This suggests that diffusion of neurotransmitter out of the synapse prior to uptake will be more important than previously thought. This does not diminish the overall importance of transport and uptake, but would slightly alter our view ofthe synaptic process. Supported ny NIH grants RR00165 and DA10732.

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Presentation Number SAkuhar0153
Keywords: neurotransmitter, transporter, synapse, uptake, dopamine

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Kuhar, M; (1998). Neurotransmitter Transporters Are NOT in the Synapse?. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/simantov/kuhar0153/index.html
© 1998 Author(s) Hold Copyright