Neuropharmacology Poster Session
Recio, J. (Dept. Physiology and Pharmacology, School of Medicine, Univ. Cantabria, Spain)
Paz-Valinas, L. (Dept. Animal Physiol, School of Biol., Univ. Santiago de Compostela, Spain)
Aldegunde, M. (Dept. Animal Physiol, School of Biol., Univ. Santiago de Compostela, Spain)
Sanchez-Barcelo, EJ (Dept. Physiology and Pharmacology, School of Medicine, Univ. Cantabria, Spain)
This study examines the age-associated changes in noradrenaline (NA), dopamine (DA), 3,4-dihydroxyphenyl-acetic acid (DOPAC), serotonin (5-HT) and 5-hydroxy-3-indoleacetic acid (5-HIAA) in different brain areas of rats. DA and DOPAC concentrations in striatum increased at third month of age, remaining without significant variations until 12th month of age, and decreasing in 24-month-old rats. DA concentration dropped in hippocampus, amygdala and brainstem of 24-month-old-rats, whereas DOPAC levels decreased only in hippocampus. These changes suggest an age-dependent deficit of dopaminergic system, presumably related with a reduced number/activity of DA nigrostriatal and mesolimbic neurons. An age-induced decline in NA content was found in the pons-medulla, the area containing NA neuronal bodies. Concentrations of 5-HT were reduced with aging in frontal cortex, showing a tendency to decrease in all brain areas examined. The increased 5-HIAA/5-HT ratio found in frontal cortex, amygdala and striatum suggests an age-related decreased synthesis and an accelerated 5-HT metabolism. The 5-HIAA content decreased in brainstem of the oldest rats. These findings point to a selective impairment of nigrostriatal and mesolimbic DA in aging rats, whereas reductions in NA were restricted to cell bodies region and 5-HT showed changes of different extent in areas of terminals and neuronal cell bodies.
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|Miguez, JM.; Recio, J.; Paz-Valinas, L.; Aldegunde, M.; Sanchez-Barcelo, EJ; (1998). Aging-induced Changes in Monoamine Neurotransmitters of Different Brain Regions of the Rat. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuropharm/miguez0364/index.html|
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