Neuropharmacology Poster Session
Sugimoto, Y. (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan)
Kamei, C. (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan)
The effect of endogenous histamine on spatial cognition was investigated with 8-arm radial maze in rats. Intracerebroventricular (i.c.v.) injection of Éø-fluorome thylhistidine (Éø-FMH), a selective inhibitor of histidine decar- boxylase, resulted in spatial memory deficits, which are characterized by an increase in the number of total error (TE) and a decrease in the number of initial correct response (ICR). There is a high correlation between an increase in the number of TE and a decrease in histamine contents of the cortex and hippo- campus, which are known to partici pate in learning and memory. On the other hand, both histamine (50-100 ng, i.c.v.) and thioperamide (10*É mg(microgrammer), i.c.v.) signi- ficantly ameliorated on memory deficit induced by Éø-FMH. However, metoprine showed no significant effect on Éø FMH-induced memory deficit. Pyrilamine and R-(Éø)-methylhistamine enhanced the memory deficit induced by Éø-FMH, at doses which caused no appreciable effect when they were given alone. In contrast, no significant influence was observed with zolantidine in Éø-FMH-induced memory deficit.
Back to the top.
| Discussion Board | Next Page | Your Poster Session |
|Chen, Z.; Sugimoto, Y.; Kamei, C.; (1998). Influence of endogenous histamine in 8-arm radial maze performance in rats. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuropharm/chen0322/index.html|
|© 1998 Author(s) Hold Copyright|