Neuropharmacology Poster Session




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Retrieval of Memory Traces: Pharmacological Regulation of Separate Steps.

Arkhipov, V. (Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Russia)

Contact Person: Vladimir I Arkhipov (arkhipov@arkhipov.iteb.serpukhov.su)


Long-term memory is represented in widely distributed cortical cells. For this reason, the retrieval of memory traces is the principal process for understanding of memory realization at available environment. Findings from behavioral pharmacology pointed out the existence of definite steps for the retrieval processes: i.) The selection of appropriate cluster of engrams; ii.) The inhibition of unessential components and strengthening of substantial ones; iii.) The estimation of selected engrams on suitableness to available circumstances. The retrieval steps can be revealed, when two phenomena are compared: drug discrimination and pharmacologically induced state-dependent retrieval of responses. During drug discrimination learning the drugs substitute for external stimuli, therefore the main point for understanding of this phenomenon is sensory process. When memory dissociation occurs, the retrieval of engrams is dependent on neurochemical status of the brain. Dissociated retrieval of responses is possible if some part of memory traces is blocked side by side with another traces are available for reproduction. The stage of the engram selection is accessible for pharmacological regulation. This suggests by the possibility of gradual retrieval of dissociated responses under influences of various doses of drugs. Possibly, cholinergic and GABA-ergic systems of hippocampus play the key role in regulation of long-term memory retrieval.

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Poster Number PAarkhipov0328
Keywords: memory retrieval, dissociation of, memory, cholinergic

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Arkhipov, V.; (1998). Retrieval of Memory Traces: Pharmacological Regulation of Separate Steps.. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/neuropharm/arkhipov0328/index.html
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