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The Change of Ocular Blood Flow after Topical Instillation of Unoprostone Eye Drops

Emi, K (Emi Eye Clinic, Mie, Japan)
Ito, Y (Mie General Medical Center, Mie, Japan)
Nishi, A (Mie General Medical Center, Mie, Japan)
Uji, Y (Department of Ophthalmology, Mie University School of Medicine, Japan)

Contact Person: Kazuo Emi (emiganka@inetmie.or.jp)


Purpose: To assess the change of ocular blood flow after topical application of unoprostone(prostaglandin-related compound) eye drops on the normal subjects. Subjects and Method: Eighteen normal subjects were examined, including fourteen females and four males. The averaged age was 71 years old, ranging from 60 to 84 years old. The LOGIQ500 color Doppler imaging unit was used to examine all of the subjects. Before and two hours after the application of unoprostone, we tried the color Doppler imaging and pulse Doppler method to detect the blood flow of the CRA and PCA. Results: Peak-systolic, mean and end-diastolic blood flow velocities were increased after the instillation of unoprostone for both CRA and PCA.(p > 0.01) Pulsatility indices were not changed in both vessels. Conclusion: The unoprostone improves the ocular blood circulation of the orbital vessels.

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Presentation Number SAemi0140
Keywords: Unoprostone, Ultrasonography, Human eye, eye blood flow

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Emi, K; Ito, Y; Nishi, A; Uji, Y; (1998). The Change of Ocular Blood Flow after Topical Instillation of Unoprostone Eye Drops. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/nemeth/emi0140/index.html
© 1998 Author(s) Hold Copyright