Invited Symposium: Molecular Mechanisms of Ageing



Materials and Methods





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Aging and Resistance to Oxidative Damage in Caenorhabditis elegans

Ishii, N (Department of Molecular Life Science, Tokai University School of Medicine, Japan)
Hartman, P (Department of Biology, Texas Christian University, USA)

Contact Person: Naoaki Ishii (nishii@is.icc.u-tokai.ac.jp)


Much attention has focused on the role that oxidative damage plays in cellular and organismal aging. The C. elegans gene mev-1 confers resistance to oxidative stress and modulates longevity. We have cloned mev-1 by transformation rescue and found that it encodes cyt-1 encoding the large subunit of succinate dehydrogenase cytochrome b. A missense mutation abolishes complex II activity in the mitochondrial membrane. These data indicate that CYT-1 participates to mediate electron transfer. Moreover, mutational inactivation of this process renders animals susceptible to oxidative stress and as a result, leads to precocious aging.

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Presentation Number SAishii0263
Keywords: ageing, oxidative stress, C. elegans, mev-1, cytochrome b

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Ishii, N; Hartman, P; (1998). Aging and Resistance to Oxidative Damage in Caenorhabditis elegans. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/higuchi/ishii0263/index.html
© 1998 Author(s) Hold Copyright