Arachidonic Acid Metabolites, Other Inflammatory Mediators and Intestinal Ion Transport

Question for Dr. Barrett (or anyone else who cares to answer)

W.K. MacNaughton

Kim, nice review of a complicated topic.  What is known of the role of mast cell-derived proteases in regulating transport? I know that the effect of rat mast cell protease II (RMCP-II) has been tested on epithelial permeability, but effects on ion transport are less clear. Is there, to your knowledge, a physiological role for serine proteases in ion transport, either physiological or pathophysiological?
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