Wally - thanks for the question. There is remarkably little known. As you say, RMPCII appears to induce epithelial sloughing and therefore has profound effects on permeability. We tried a few experiments a long time ago looking at the effects of purified human tryptase and chymase on T84 cells and didn't see much, if anything. But I think it is possible that at least some of these proteases may alter sensitivity to other agonists, which has been described for human proteases on smooth muscle. But there is not a huge supply of the purified proteases out there to test this in any systematic way.
Hope all is well for you in the frozen north!