Arachidonic Acid Metabolites, Other Inflammatory Mediators and Intestinal Ion Transport

Comment on Isoprostanes


This is a response to MacNaughton and Unmack. Re: Isoprostanes, very little is known about the changes in intestinal inflammation. We have a comment about it in our JPET paper (Elmhurst et al Nov 1997), which was added in response to a query by one of the referees. s/he was curious about that as well. Much of the work in the isoprostane field has been done by investigators interested in cardiovascular/respiratory/renal problems. We were hoping to interest GI physiologists/pharmacologists in this area. The presence of the isoprostanes as well as the CYP metabolites of AA  suggest that the effects of  selective COX inhibition may be muted.  
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