Novel Cellular and Molecular Mechanisms in Allergic Inflammation

Re: Starting comments on the presentation by Matthaei et al


On Sat Dec 5, Judah Denburg wrote
>Dear Klaus (and Paul/Ian):

>There are examples in clinical medicine other than intrinsic asthma which may point to a separate and distinct contributory role for CD4 (and possibly CD8) cells in eosinophilic inflammation: namely, nasal polyposis (associated with intrinsic asthma) and occupational asthma.

>The million dollar question is obviously: which cytokine(s) mediate the CD4 effect in your mouse model?

>Judah Denburg

Dear Judah

Do you mean in the development of the CD4 cell or its recruitment to the lung?  Perhaps interleukin-13 can replace some of the IL-4 mediated functions and there is evidence in some mouse systems that IL-16 is important in recruitment.

Paul Foster, Ian Young, Klaus Matthaei

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