Novel Cellular and Molecular Mechanisms in Allergic Inflammation

Starting comments on the presentation by Matthaei et al

Judah Denburg

Dear Klaus (and Paul/Ian):

There are examples in clinical medicine other than intrinsic asthma which may point to a separate and distinct contributory role for CD4 (and possibly CD8) cells in eosinophilic inflammation: namely, nasal polyposis (associated with intrinsic asthma) and occupational asthma.

The million dollar question is obviously: which cytokine(s) mediate the CD4 effect in your mouse model?

Judah Denburg

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