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In Vivo Examination Of Effects Of Creams And Ointments On Stratum Corneum Using 100 MHz Sonography

Kaspar, K. (Department of Dermatology of the Ruhr-University, Germany)
el Gammal, S. (Department of Dermatology of the Ruhr-University, Germany)
Altmeyer, P. (Department of Dermatology of the Ruhr-University, Germany)
Vogt, M. (Institute for High Frequency Engineering of the Ruhr-University, Germany)
Ermert, H. (Institute for High Frequency Engineering of the Ruhr-University, Germany)

Contact Person: Katharina Kaspar (katharina.kaspar@ruhr-uni-bochum.de)


Abstract

To visualize epidermal effects of different locally applied ointments and creams by means of high-frequency-sonography, it is necessary to use frequencies well above 20 MHz. We studied the effects of vaseline, of an oil-in-water-emulsion, of a water-in-oil-emulsion and of a 10 % urea in oil-in-water-emulsion on the finger pads of 10 patients by using a 100 MHz ultrasound unit (axial resolution 9 Ám, lateral resolution 27 Ám). The test sites were evaluated sonographically after an occlusion period of 30, 60, 120, 180, and 240 minutes. The water content and the additives (e.g. urea) had a great influence on the sonographic image. All images were evaluated by using image analysis. We observed a significant thickening (p < 0.05) of the stratum corneum on the finger pads, a density alteration of stratum corneum and a reduction of the echogenicity of the skin entry echo. We conclude, that the 100 MHz sonography is well suited to evaluate the epidermal effects of externals in follow-up studies.

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Poster Number PAkaspar0548
Keywords: Sonography, Ointments, Creams, Stratum Corneum, High Frequency


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Kaspar, K.; el Gammal, S.; Altmeyer, P.; Vogt, M.; Ermert, H.; (1998). In Vivo Examination Of Effects Of Creams And Ointments On Stratum Corneum Using 100 MHz Sonography. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/newtech/kaspar0548/index.html
© 1998 Author(s) Hold Copyright