New Technology Poster Session
To visualize the epidermal effects of different locally applied ointments and creams using sonography, an ultrasound transducer with a significant higher axial and lateral resolution than in the commercially available 20 MHz machines is necessary.
Materials and Methods
The 100 MHz ultrasound imaging unit consists of an applicator with the transducer (PZT), a transient recorder, a control unit and a computer.
A couple of "short" B-Scans is acquired at different depths of the tissue by mechanical movement of the transducer with respect to the depth direction (D-axis) between each acquisition.
Water is used as coupling medium. After placing the applicator on the skin, the plexiglas chamber is filled with water.
Three stepper motors are housed in the applicator which enable a precise movement of the transducer in all three axes.
We studied the effects of five different creams and ointments on the finger pads after occlusion of 10 healthy persons.
The occlusion was done with one square-centimeter Finn-Chambers.
Creams and ointments
We chose the following creams and ointments:
Figure 1 shows the sonogram of the finger pad before therapy:
The top echorich line is the skin entry echo.
The thickening of the stratum corneum is already visible clinically.
Figure 2 shows the effect of the oil-in-water-emulsion on the same finger pad
and figure 3 the corresponding sonogram after 30 minutes occlusion with the oil-in-water-emulsion.
A significant thickness increase of the stratum corneum can be seen.
Figure 4 summarizes the thickness increase of the stratum corneum at different time periods using the various ointments.
The fastest and largest thickness increase of the stratum corneum is observed under the oil-in-water-emulsion and water.
Discussion and Conclusion
The thickness increase of the stratum corneum is due to an increase in humidity, which is a direct effect of water-containing externals or which is due to a reduction of vaporisation in fat-containing externals.
We observed the following effects of locally applied externals on the ultrasound image:
We conclude, that 100 MHz sonography therefore is well suited to evaluate the epidermal effects of topically applied substances in follow-up studies.
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|Kaspar, K.; el Gammal, S.; Altmeyer, P.; Vogt, M.; Ermert, H.; (1998). In Vivo Examination Of Effects Of Creams And Ointments On Stratum Corneum Using 100 MHz Sonography. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/newtech/kaspar0548/index.html|
|© 1998 Author(s) Hold Copyright|