Cell Biology Poster Session
Skepper, J.N (Multi-Imaging Centre, Department of Anatomy, Cambridge University, UK)
Wooding, P.B.P (Babraham Institute, Babraham, Cambridge, UK)
Burton, G.J (Department of Anatomy, Cambridge University, UK)
In this study, we report the ultrastructure of the interstitial trophoblast cell population in the first trimester human decidua basalis between 7 and 12 weeks gestation. The phenotype of the cells is characterised using immunogold labelling techniques. There is clear evidence of two morphologically distinct cell populations of the interstitial trophoblast designated type I electron-lucent, agranular and the type II electron-dense, granular interstitial trophoblast cells. Both cell populations are reactive for cytokeratin, an observation which indicates their trophoblastic nature and confirms their epithelial origin. Immunogold labelling using anti-human placental lactogen demonstrated the presence of the placental protein within cytoplasmic granules clearly indicating their origin as interstitial trophoblast. Significant difference were found in the volume fraction of granule between the three cell types. Differences were also found in the volume fraction of mitochondria and Golgi apparatus between the maternal leucocytes and the type I cells.
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|Al-Lamki, R.S; Skepper, J.N; Wooding, P.B.P; Burton, G.J; (1998). The Interstitial Trophoblast of the First Trimester Human Decidua Basalis Is Composed of Two Distinct Cell Types: an Ultrastructural and Immunocytochemical Study. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/cellbio/al-lamki0114/index.html|
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