Quinones and Other Reactive Oxygen Species in Neurobiologic, Apoptotic, and Neurotoxic Processes

Toxicity of dopamine/dopaminochrome on cultured cells

Richard M. Kostrzewa

Your findings indicate that genetics have an important role in protecting neurons from oxidative damage. Those kinds of cells with an enzymatic composite that produce a high level of antioxidant defenses are least susceptible to oxidative injury. However, it is difficult to establish a familial line in Parkinson's disease. In other words, except for isolated studies, there does not appear to be a genetic basis for Parkinson's disease. Can you please put your findings in this context to address the possible link in your studies to susceptibility to Parkinson's disease?
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