Quinones and Other Reactive Oxygen Species in Neurobiologic, Apoptotic, and Neurotoxic Processes

No title!

Jean Lud Cadet, M.D.

Professor Smythies has offered an impressive review about what we know and do not know about catecholamines. It is interesting, however, that there are abnormalities in non-catecholaminergic systems even in those disorders that are thought to be mediated by monoaminotoxins. Is it possible that there exists in these disorders a primary genralized toxin whose toxicity is exacerbated in catecholaminergic neurons? If that is the case, is our emphasis on dopamine as a toxin exaggerated? I would like to hear what others think about this.
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