Oxidative Stress and the CNS

Inducible nitric oxide synthetase and manganesesuperoxide dismutase expression in primary cultures of rat glial cells

Richard M. Kostrzewa

Your data show that oligodendroglia lack Mn SOD and iNOs, and you pose the hypothesis that oligodendroglia vulnerability to  oxidative stress could result in their demise in certain situations and in demyelinating disorders. This would be especially so, if those cells had high iron content and/or inducible heme oxygenase. Has anyone determined this for oligodendroglial cells?
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