Oxidative Stress and the CNS


Re: Inducible nitric oxide synthetase and manganesesuperoxide dismutase expression in primary cultures of rat glial cells

Bernhard H.J. Juurlink
juurlink@duke.usask.ca


We have shown that immature oligodendroglia in cultures have high iron content (Thorburne and Juurlink.  1996.  J. Neurochem. 67:1014) and immature oligodendroglia can express HO1 following an hypoxic-ischemic insult (Brain Research Interactive, 1998).   Connor and colleagues have demononstrated that oligodendroglia in the CNS have high iron contents (e.g., J. Comp. Neurol. (1993) 338: 97 & Develop. Neurosci. (1994) 16:233)
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