Oxidative Stress and the CNS

Re: Inducible nitric oxide synthetase and manganesesuperoxide dismutase expression in primary cultures of rat glial cells

Bernhard H.J. Juurlink

We have shown that immature oligodendroglia in cultures have high iron content (Thorburne and Juurlink.  1996.  J. Neurochem. 67:1014) and immature oligodendroglia can express HO1 following an hypoxic-ischemic insult (Brain Research Interactive, 1998).   Connor and colleagues have demononstrated that oligodendroglia in the CNS have high iron contents (e.g., J. Comp. Neurol. (1993) 338: 97 & Develop. Neurosci. (1994) 16:233)
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