Oxidative Stress and the CNS

Re: Symposium 439

Bernhard H.J. Juurlink

Dear Dr. Grover,  There is much evidence from in vitro work that astrocytes can give protection to oligodendrocytes.  This may be by 1) scavenging strong oxidants in the oligodendrocyte's microenvironment as demonstrated by Dr. Yong's laboratory, or possibly by 2) reducing cystine to cysteine and transferring cysteine to oligodendrocytes (cysteine is more readily taken up by cells than is cystine) as has been demonstrated for neurons by Dr. Sagara and colleagues, or 3) by the release of yet unidentifed factors by astrocytes that enable oligodendrocytes to withstand oxidative stress.

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