Glaucoma: Diagnosis and Therapy



Dr. Budde: Thanx for the response.
On Fri Dec 11, Wido M Budde wrote
>Dear Dr. Grover,
>One pathogenetic concept of glaucomatous optic atrophy is the mechanical distortion of the retinal nerve fibers at the level of the lamina cribrosa along the pressure gradient intraocular - extraocular. Possibly, the central retinal vessel trunc may act as stabilizing element against a pressure induced deformation of the lamina cribrosa and, by that, against a secondary alteration of the optic nerve fibers (and/or capillaries ?) in the lamina cribrosa. It suggests that the closer the neuororetinal rim to the vessel trunc, the less marked may be the glaucomatous damage.

>Jost Jonas
>On Sun Dec 6, Grover wrote
>>Dr. Jonas: Great presentation.  Hope you have fun at the meeting.You indicate that the pathogenetic reason for the finding of the present study, that glaucomatous parapapillary atrophy partially depends on the distance to the central retinal vessel trunk exit, remains unclear.  What sort of primary causes would you think initiate such a damage?  Association studies may be useful therapeutically but from these how does one lead to the primary cause?

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