Re: Poster 842
On Sun Dec 6, Grover wrote
>Dr. Grunze: Hope you are enjoying the meeting. Great poster.Could you clarify for me whether based on these results you think that valproate worked only in one patient because acute mania is a multifactorial disorder or because there is difference between patients in the bioavailability of valproate in the brain areas which would be affected by it?
Sorry for the late reply. Just to clarify it :4/5 were considered as responders, the non- responder was a ultra-ultra rapid cycling patient. This is, in my opinion, a clearly different state from "normal" bipolar, and seems to be more sensitive to agents regulating intracellular calcium homeostasis. I think that the difference in the presumably underlying pathophysiology explains the non- response in this very special patient.
Thu Dec 10