Mathew T. Martin-Iverson
>This is an interesting study. I have been fascinated by your original observations for some time and I am glad that you are back studying the phenomenon again. Do you intend attempting suprachiasmatic nucleus destruction in rats infused with PHNO? I suspect that the tolerance sensitisation is occurring at a site innervated by efferents from the SCN. The tracing literature should give you some clues where to look further.
Thanks for your interest - I wish granting agencies felt the same way, but neither Canadian nor Australian granting bodies seem to like the circadian rhythms in the development of tolerance/sensitisation (hence the period of no research in the area). I am currently looking for a student who may be interested in doing SCN lesions ...