MAOIs: Multiple Effects and
Sites of Action
Symposium 524 Beth Levant
blevant@kumc.edu
Hi Kirsten. �What a nice presentation. �You've done a lot of work. Checking out the effects of clorgyline and moclobemide on [DA] and MAO activity was really important and rules out the possibility that the effects on quinpirole sensitization are due to chronic modulation of dopaminergic tone. �Likewise, it is unlikely that chronic alterations 5-HT of NE are involved.I'm not sure what the affinity of moclobemide is for the I2 site. �Is it similar to Ro 41-1049?
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Tue Dec 8