With regards to moclobemide's affinity for brain I2 sites, it would appear that moclobemide doesn't compete against [3H] idazoxan binding at I2 imidazoline preferring receptors. Ro 41-1049 isn't much better, displacing [3H] idazoxan binding with a very low potency (Ki=79,000nM). Clorgyline, on the other hand, has a very high affinity for the I2 site (Ki=0.04nM).
Hope you are enjoying the conference. I'll be in touch in the new year to let you know when I will be sending you the next group of brains!
Have a great holiday,
[ This message was edited on Thu Dec 10 by the author ]