Hypertension I: Structure of Small Arteries in Hypertension

To Dr Lee

Denis deBlois

Congratulations for the careful study.
In your opinion, is in situ fixation at physiological pressure a reliable method to evaluate changes in vascular tone, lets say in response to acute infusion of a vasoconstrictive agent such as an alpha-adrenergic agonist?
Your study suggest that fixation itself may introduce an artefactual reduction in lumen size. Can this be controled ?
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